Robert Haining@rhaining Active 1 year, 6 months ago
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Associate Professor of Chemistry; specializing in biotechnology, biochemistry and organic chemistry. Dr. Haining has expertise in drug metabolism and pharmacogenetics. He taught at West Virginia University in the School of Pharmacy where he held an R01 grant from the National Institutes of Environmental Health Sciences (NIEHS) prior to accepting his current teaching and research position at GGC. His research interests now focus on the role of neuromelanin in human brain. Neuromelanin is a spontaneously forming polymer of dopamine that is retained for life in normal individuals, yet whose function is largely unknown.
Haining R., Sloop J.C. (2018) “A New Model for Advanced Undergraduate Chemistry Laboratory Courses: A Two-semester Integrated Laboratory Experience” Journal of Laboratory Chemical Education 6(2): 24-30 doi:10.5923/j.jlce.20180602.02
Haining R.L., Jones T. and Hernandez A. (2016) “Saturation binding of nicotine to synthetic neuromelanin demonstrated by fluorescence microscopy” Neurochemical Research 41: 3356-3363 DOI: 10.1007/s11064-016-2068-9
Haining R.L. and Achat-Mendes C. (2017) “Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator” Neural Regeneration Research 12: 372-375 DOI: 10.4103/1673-5374.202928
Russell J.E., D’Costa A.R., Runck, C., Barnes D.W., Barrera A.L., Hurst-Kennedy J., Sudduth E.B., Quinlan E.L., Schlueter M., Iskhakova L.A., and Haining, R. (2017) “Correction for Bridging the Undergraduate Curriculum Using an Integrated Course-Embedded Undergraduate Research Experience (ICURE).” CBE Life Sciences Education 16(1):co3. doi:10.1187/cbe.14-09-0151-corr
Sloop, J., Cole, H., Costello, G., Pursell, D., Haining, R. and Helms, J. (2014) Design, Synthesis and Bioactivity of Fluorinated Sulfa Drugs. Conference proceedings from the Ninety-First Annual Meeting of the Georgia Academy of Science, Valdosta State University, Valdosta, Georgia; 03/2014
Runck, C., Russell, J., D’Costa, A., Schlueter, M., Barrera, A., Barnes, D., and Haining, R. (2012) Inclusive and longitudinal educational research tools for promoting engaged student learning: Bridging the undergraduate experience with biodiversity and DNA barcoding. Conference proceedings from the 97th Entomological Society of America Annual Convention 2012; 08/2012
Zhang, W. Y., Tu, Y. B., Haining, R. L., and Yu, A. (2009) “Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, AND CYP2D7 isozymes.” Drug Metabolism and Disposition 37: 1-4
Yu, A. and Haining, R. L. (2006) “Expression, purification and characterization of mouse CYP2d22”. Drug Metabolism and Disposition 34:1167-74.
Paine, M. F., Hart, H. L., Ludington, S. S., Haining, R. L., Rettie A. E. and Zeldin, D. C. (2006) “The human intestinal cytochrome P450 ‘pie’” Drug Metabolism and Disposition 34: 880-886.
Bland, T. M., Haining, R. L., Tracy, T. S., and Callery, P. S. (2005) CYP2C-catalyzed ?(9)-tetrahydrocannabinol metabolism: Kinetics, pharmacogenetics and interaction with phenytoin. Biochemical Pharmacology 70: 1096-1103.
Hummel M. A., Dickmann L. J., Rettie A. E., Haining R. L., and Tracy T. S. (2004) Differential activation of CYP2C9 variants by dapsone. Biochemical Pharmacology 67:1831-41.
Yu, A., Kneller, B., Rettie, A. E., and Haining, R. L. (2002) Expression, purification, biochemical characterization and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10 and 2D6.17 allelic isoforms. Journal of Pharmacology and Experimental Therapeutics 303:1291-1300.
Ramamoorthy, Y., Yu, A-M., Suh, N., Haining, R. L., Tyndale, R. F., and Sellers, E. M. (2002) Reduced (+)3,4-methylenedioxymethamphetamine (“ecstasy”) metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochemical Pharmacology 63:2111-9.
Suzuki, H., Kneller, B. M., Haining, R. L., Trager, W. F. and Rettie, A. E. (2002) (+)-N-3-benzyl-nirvanol and (-)-N-3-benzyl-phenobarbitol: new potent and selective in vitro inhibitors of CYP2C19. Drug Metabolism and Disposition 30:235-239.
Tracy, T. S., Hutzler, J. M., Haining, R. L., Rettie, A. E., Hummel, M., and Dickman, L. J. (2002) Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles. Drug Metabolism and Disposition 30: 385-390.
Yu, A., Dong, H., Lang, D. and Haining, R. L. (2001) Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6. Drug Metabolism and Disposition 29: 1362-1365.
Yu, A. and Haining, R. L. (2001b) Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CYP2D6 and CYP3A activities? Drug Metabolism and Disposition 29: 1514-1520.
Kilicarslan T., Haining R. L., Rettie A. E., Busto U., Tyndale R. F. and Sellers E. M. (2001) Flunitrazepam metabolism by cytochrome P450s 2C19 and 3A4. Drug Metabolism and Disposition 29: 460-465.
Dong, H., Haining, R. L., Thummel, K. E., Rettie, A. E. and Nelson, S. D. (2000) Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metabolism and Disposition 28: 1397-1400.
Rettie, A. E., Haining, R. L., Bajpai, M., and Levy, R. H. (1999) A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin. Epilepsy Research 35: 253-255.
Haining, R. L., Jones, J. P., Henne, K. R., Fisher, M. B., Trager, W. F. and Rettie, A. E. (1999) Enzymatic determinants of the substrate specificity of CYP2C9: role of B’-C loop residues in providing the pi-stacking anchor site for warfarin binding. Biochemistry 38: 3285-3292.
Koenigs, L. L., Peter, R. M., Hunter, A. P., Haining, R. L., Rettie, A. E., Friedberg, T., Pritchard, M. P., Shou, M., Rushmore, T. H., and Trager, W. F. (1999) Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9. Biochemistry 38: 2312-2319.
Haining, R. L., Hunter, A. P., Sadeque, A. J. M., Philpot, R. M. and Rettie, A. E. (1997) Baculovirus-mediated expression and purification of human FMO3: catalytic, immuno-chemical, and structural characterization. Drug Metabolism and Disposition 25: 790-797.
Steward, D. J., Haining, R. L., Henne, K. R., Davis, G., Rushmore, T. H., Trager, W. F. and Rettie, A. E. (1997) Genetic association between sensitivity to warfarin and expression of CYP2C9*3. Pharmacogenetics 7: 361-367.
Tugnait, M., Hawes, E. M., McKay, G., Rettie, A. E., Haining, R. L. and Midha, K. K. (1997) N-oxygenation of clozapine by flavin-containing monooxygenase. Drug Metabolism and Disposition 25: 524-527.
Haining, R. L., Hunter, A. P., Veronese, M. E., Trager, W. F. and Rettie, A. E. (1996) Allelic variants of human cytochrome P-450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms. Archives of Biochemistry and Biophysics 333: 447-458.